APBB3

Across TCGA cell cohorts, APBB3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APBB3-associated genes across cancer lineages are OR10W1, CD300H, and ASB17. Each is linked with APBB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both APBB3-to-partner and partner-to-APBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by APBB3-low versus APBB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB3→partner) and Y-score (partner→APBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.045	+5.415	<.001	.004	3	1
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
CNS	CST11 →	+0.065	+4.981	.006	.008	3	1
CNS	CST9 →	+0.046	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR10W1 by APBB3 expression — LARGE_INTESTINE

Explore this box plot interactively →