APBB2

Across TCGA patient cohorts, APBB2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBB2-associated genes across cancer lineages are Ku80, MEK1, and STAT3_pY705. Each is linked with APBB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APBB2-to-partner and partner-to-APBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by APBB2-low versus APBB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB2→partner) and Y-score (partner→APBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.188	+1.293	.027	.037	3	2
UCEC	MEK1 →	+0.563	+3.906	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.525	-2.652	<.001	<.001	3	2
UCEC	ASNS →	+0.424	+2.700	.001	.006	3	2
UCEC	ATM →	-0.623	-1.925	<.001	.005	3	2
UCEC	4E-BP1 →	+0.407	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Ku80 by APBB2 expression — UCEC

Explore this box plot interactively →