APBB2

Across TCGA cell cohorts, APBB2 mutation is significantly associated with the RNA expression of many other genes, with 369 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APBB2-associated genes across cancer lineages are NPBWR2, ZSCAN1, and TBL1Y. Each is linked with APBB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both APBB2-to-partner and partner-to-APBB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPBWR2 grouped by APBB2-low versus APBB2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB2→partner) and Y-score (partner→APBB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NPBWR2 →	+0.012	+5.000	.002	.006	3	1
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
CNS	HSFY1 →	+0.015	+4.981	.001	.008	3	1
LARGE_INTESTINE	CBY1 →	+0.676	+3.299	<.001	.004	3	1
LARGE_INTESTINE	ERI1 →	+0.791	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 369 associations by consensus.

NPBWR2 by APBB2 expression — PANCREAS

Explore this box plot interactively →