APBB1

Across TCGA pan-cancer cohorts, APBB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated APBB1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher APBB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated APBB1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where APBB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.768	0.499	.003	33	view →
CCRCC	OS	Quartile	All	0.876	0.669	.023	8	view →
PDAC	DFS	Median	III,IV	0.425	0.780	.008	7	view →
UCEC	DFS	Median	II,III,IV	0.518	0.882	.030	4	view →
GBM	DFS	Quartile	All	0.879	0.760	.039	1	view →
HNSC	OS	Quartile	IV	1.000	0.715	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

APBB1–LUAD (DFS)

Open the LUAD breakdown →