APBB1

Across TCGA pan-cancer cohorts, APBB1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of APBB1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where APBB1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types APBB1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where APBB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in APBB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	−0.783	<.001	9	view →
LUAD	Female	III,IV	−0.698	<.001	9	view →
HNSC	Male	II,III,IV	−0.567	<.001	8	view →
COAD	All	All	−0.823	.021	6	view →
PDAC	All	All	−0.344	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

APBB1–LSCC

Open the LSCC breakdown →