APBB1

Across TCGA patient cohorts, APBB1 mutation is significantly associated with the RNA expression of many other genes, with 4,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBB1-associated genes across cancer lineages are NARS1, SLC7A11, and GPR180. Each is linked with APBB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both APBB1-to-partner and partner-to-APBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NARS1 grouped by APBB1-low versus APBB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB1→partner) and Y-score (partner→APBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NARS1 →	+0.443	+2.502	<.001	<.001	3	4
UCEC	SLC7A11 →	+0.764	+1.784	<.001	<.001	3	3
UCEC	GPR180 →	+0.462	+1.584	<.001	.001	3	3
UCEC	SUPV3L1 →	+0.300	+1.595	.002	<.001	3	3
SKCM	ZNF330 →	+0.528	+3.334	.008	.005	3	3
SKCM	MASTL →	+0.695	+3.341	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,713 associations by consensus.

NARS1 by APBB1 expression — UCEC

Explore this box plot interactively →