APBB1

Across TCGA patient cohorts, APBB1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBB1-associated genes across cancer lineages are PDCD4, Annexin-1, and ATM. Each is linked with APBB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both APBB1-to-partner and partner-to-APBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by APBB1-low versus APBB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB1→partner) and Y-score (partner→APBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.472	-2.087	.001	.004	3	3
UCEC	Annexin-1 →	+0.541	+2.107	<.001	.002	3	3
UCEC	ATM →	-0.480	-2.087	<.001	.005	3	3
UCEC	STAT3_pY705 →	-0.290	-1.797	<.001	.003	3	3
COAD	EGFR_pY1068 →	-0.462	-3.446	<.001	.005	3	2
COAD	Fibronectin →	+0.637	+2.593	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

PDCD4 by APBB1 expression — UCEC

Explore this box plot interactively →