APBB1

Across TCGA cell cohorts, APBB1 mutation is significantly associated with the RNA expression of many other genes, with 263 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APBB1-associated genes across cancer lineages are AVP, SPAG11A, and KRTAP4-5. Each is linked with APBB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APBB1-to-partner and partner-to-APBB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by APBB1-low versus APBB1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBB1→partner) and Y-score (partner→APBB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AVP →	+0.046	+5.781	<.001	.001	3	2
OVARY	SPAG11A →	+0.041	+3.990	<.001	.003	3	1
OVARY	KRTAP4-5 →	+0.052	+4.222	<.001	.006	3	1
OVARY	KRTAP4-12 →	+0.155	+3.700	<.001	.005	3	1
OVARY	KRTAP1-5 →	+0.736	+3.898	<.001	.005	3	1
OVARY	OR14A2 →	+0.054	+3.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 263 associations by consensus.

AVP by APBB1 expression — BREAST

Explore this box plot interactively →