APBA3

Across TCGA cell cohorts, APBA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,899 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible APBA3-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Subtelomeric heterochromatin formation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with APBA3 in more than 15 cancer types. Because this analysis shows association rather than direction, both APBA3-to-partner and partner-to-APBA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by APBA3-low versus APBA3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APBA3→partner) and Y-score (partner→APBA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.176	+0.748	<.001	<.001	3	16
BONE	Subtelomeric heterochromatin formation →	+0.120	+0.647	<.001	<.001	3	16
BLOOD_Leukemia	Negative regulation of transcription initiation by RNA polymerase II →	+0.118	+0.607	<.001	<.001	3	15
URINARY_TRACT	Negative regulation of telomere maintenance →	+0.080	+0.686	<.001	<.001	3	15
BLOOD_Leukemia	Negative regulation of DNA-templated transcription initiation →	+0.118	+0.607	<.001	<.001	3	15
BONE	Negative regulation of protein localization to chromatin →	+0.187	+0.702	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,899 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by APBA3 expression — BONE

Explore this box plot interactively →