APBA2

Across TCGA patient cohorts, APBA2 mutation is significantly associated with the RNA expression of many other genes, with 4,705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APBA2-associated genes across cancer lineages are UBE2M, RPF1, and GPATCH3. Each is linked with APBA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both APBA2-to-partner and partner-to-APBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2M grouped by APBA2-low versus APBA2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBA2→partner) and Y-score (partner→APBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	UBE2M →	+0.399	+2.127	<.001	.009	3	5
LUAD	RPF1 →	+0.482	+3.214	<.001	.009	3	5
LUAD	GPATCH3 →	+0.365	+2.700	<.001	.006	3	5
UCEC	NTMT1 →	+0.540	+2.544	<.001	<.001	3	4
COAD	THAP3 →	+0.365	+3.060	<.001	<.001	3	4
LUAD	C1QBP →	+0.621	+3.807	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,705 associations by consensus.

UBE2M by APBA2 expression — LUSC

Explore this box plot interactively →