APBA2

Across TCGA cell cohorts, APBA2 mutation is significantly associated with the RNA expression of many other genes, with 452 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APBA2-associated genes across cancer lineages are SEPSECS, ARL6, and SMAD6. Each is linked with APBA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both APBA2-to-partner and partner-to-APBA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPSECS grouped by APBA2-low versus APBA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APBA2→partner) and Y-score (partner→APBA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPSECS →	+0.666	+3.321	<.001	.003	3	2
LARGE_INTESTINE	ARL6 →	+0.449	+2.628	.004	.002	3	2
LARGE_INTESTINE	SMAD6 →	+1.188	+3.067	.001	.009	3	2
LARGE_INTESTINE	CBX4 →	+0.781	+2.628	.006	.002	3	2
LARGE_INTESTINE	PAFAH2 →	+0.596	+3.169	.001	.009	3	2
LARGE_INTESTINE	ESYT3 →	+0.983	+2.389	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 452 associations by consensus.

SEPSECS by APBA2 expression — LARGE_INTESTINE

Explore this box plot interactively →