APAF1

Across TCGA patient cohorts, APAF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,336 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible APAF1-associated proteins across cancer lineages are RIDA, ADAM17, and TIMM23. Each is linked with APAF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both APAF1-to-partner and partner-to-APAF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, APAF1 versus RIDA in COAD, with a Pearson correlation of -0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (APAF1→partner) and Y-score (partner→APAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RIDA →	-0.580	-0.295	<.001	.006	3	4
UCEC	ADAM17 →	-0.487	-0.420	<.001	<.001	3	4
BRCA	TIMM23 →	-0.437	-0.723	<.001	<.001	3	4
OV	MTDH_S308 →	-0.718	-0.549	.002	.004	3	4
OV	NEDD1 →	+0.249	+0.717	<.001	<.001	3	4
OV	PPIF →	-0.543	-0.582	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,336 associations by consensus.

APAF1 vs RIDA — COAD

Explore this scatter interactively →