APAF1

Across TCGA patient cohorts, APAF1 mutation is significantly associated with the RNA expression of many other genes, with 4,568 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APAF1-associated genes across cancer lineages are IGHVIII-5-1, RNU4-79P, and PANK4. Each is linked with APAF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both APAF1-to-partner and partner-to-APAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVIII-5-1 grouped by APAF1-low versus APAF1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APAF1→partner) and Y-score (partner→APAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGHVIII-5-1 →	+0.508	+3.255	<.001	.005	3	4
ESCA	RNU4-79P →	+0.427	+6.709	<.001	<.001	3	3
UCEC	PANK4 →	+0.378	+1.688	<.001	<.001	3	3
UCEC	PRDM8 →	+0.268	+1.375	.005	.003	3	3
UCEC	MPV17L →	-0.605	-1.484	.001	.001	3	3
UCEC	SEC13 →	+0.376	+2.424	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,568 associations by consensus.

IGHVIII-5-1 by APAF1 expression — HNSC

Explore this box plot interactively →