APAF1

Across TCGA patient cohorts, APAF1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible APAF1-associated genes across cancer lineages are 4E-BP1, PCNA, and Di-Ras3. Each is linked with APAF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both APAF1-to-partner and partner-to-APAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by APAF1-low versus APAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APAF1→partner) and Y-score (partner→APAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.315	+3.906	<.001	<.001	3	5
UCEC	PCNA →	+0.187	+1.263	.004	.019	3	3
UCEC	Di-Ras3 →	-0.160	-3.156	<.001	<.001	3	3
COAD	p53 →	-0.423	-3.161	.007	.019	3	2
COAD	Caspase-7-cleavedD198 →	+1.254	+3.178	.001	.010	3	2
SKCM	14-3-3_beta →	-0.149	-3.000	.044	.036	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

4E-BP1 by APAF1 expression — UCEC

Explore this box plot interactively →