APAF1

Across TCGA cell cohorts, APAF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,072 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible APAF1-associated GO terms across cancer lineages are Cell division, Positive regulation of organelle assembly, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with APAF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both APAF1-to-partner and partner-to-APAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell division grouped by APAF1-low versus APAF1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (APAF1→partner) and Y-score (partner→APAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cell division →	+0.091	+0.995	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.074	+1.007	<.001	<.001	3	12
BREAST	Regulation of metaphase/anaphase transition of cell cycle →	+0.110	+0.836	.002	.006	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of stress-activated MAPK cascade →	+0.091	+0.766	<.001	.002	3	12
SOFT_TISSUE	Regulation of sister chromatid segregation →	+0.108	+0.880	<.001	.001	3	12
SOFT_TISSUE	Centrosome cycle →	+0.087	+0.865	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,072 associations by consensus.

Cell division by APAF1 expression — BREAST

Explore this box plot interactively →