APAF1

Across TCGA cell cohorts, APAF1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible APAF1-associated genes across cancer lineages are OXT, SPINK9, and BTNL2. Each is linked with APAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both APAF1-to-partner and partner-to-APAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by APAF1-low versus APAF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (APAF1→partner) and Y-score (partner→APAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	2
SKIN	SPINK9 →	+0.065	+5.415	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	BTNL2 →	+0.065	+4.209	.004	.006	3	2
URINARY_TRACT	KRTAP1-4 →	+0.072	+4.087	<.001	.009	3	1
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

OXT by APAF1 expression — SKIN

Explore this box plot interactively →