AP5Z1

Across TCGA pan-cancer cohorts, AP5Z1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AP5Z1 data layer compared with 27 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher AP5Z1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP5Z1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where AP5Z1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.227	0.907	.002	9	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	6	view →
GBM	DFS	Median	All	0.632	0.785	.026	4	view →
HNSC	DFS	Quartile	III,IV	1.000	0.887	.041	1	view →
LUAD	DFS	Quartile	All	0.538	0.758	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AP5Z1–PDAC (DFS)

Open the PDAC breakdown →