AP5S1

Across TCGA pan-cancer cohorts, AP5S1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AP5S1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AP5S1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP5S1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where AP5S1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.209	0.673	.011	17	view →
PDAC	DFS	Median	All	0.645	0.912	.007	11	view →
GBM	OS	Quartile	All	0.388	0.657	.006	5	view →
UCEC	OS	Median	All	1.000	0.918	.024	4	view →
LUAD	OS	Quartile	II,III,IV	0.441	0.816	.020	2	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AP5S1–CCRCC (DFS)

Open the CCRCC breakdown →