AP5M1

Across TCGA pan-cancer cohorts, AP5M1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AP5M1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AP5M1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AP5M1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where AP5M1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.878	1.000	.014	42	view →
HNSC	OS	Tertile	All	1.000	0.107	.010	38	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	14	view →
LUAD	DFS	Median	II,III,IV	0.710	0.947	.004	7	view →
UCEC	DFS	Quartile	All	0.701	0.933	.024	6	view →
CCRCC	OS	Median	II,III,IV	1.000	0.499	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AP5M1–COAD (DFS)

Open the COAD breakdown →