AP5M1

Across TCGA patient cohorts, AP5M1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP5M1-associated genes across cancer lineages are mTOR, TFRC, and Caspase-7-cleavedD198. Each is linked with AP5M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5M1-to-partner and partner-to-AP5M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by AP5M1-low versus AP5M1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5M1→partner) and Y-score (partner→AP5M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.200	-2.999	.002	.035	3	2
UCEC	TFRC →	+0.491	+1.906	.021	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.803	+3.720	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.321	.013	.033	3	1
UCEC	MSH2 →	-0.292	-2.558	.001	.010	3	1
UCEC	NF-kB-p65_pS536 →	-0.407	-2.449	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

mTOR by AP5M1 expression — UCEC

Explore this box plot interactively →