AP5M1

Across TCGA cell cohorts, AP5M1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AP5M1-associated genes across cancer lineages are C7orf77, PRR23C, and PAX1. Each is linked with AP5M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5M1-to-partner and partner-to-AP5M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf77 grouped by AP5M1-low versus AP5M1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5M1→partner) and Y-score (partner→AP5M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C7orf77 →	+0.043	+5.000	<.001	.005	3	1
SKIN	PRR23C →	+0.013	+6.022	<.001	.001	3	1
BLOOD_Leukemia	PAX1 →	+0.034	+5.060	<.001	.001	3	1
BLOOD_Leukemia	KCNA10 →	+0.004	+4.539	.009	.007	3	1
BLOOD_Leukemia	VWC2 →	+0.397	+4.551	.002	.004	3	1
BLOOD_Leukemia	CSHL1 →	+0.016	+4.539	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C7orf77 by AP5M1 expression — KIDNEY

Explore this box plot interactively →