AP5B1

Across TCGA patient cohorts, AP5B1 mutation is significantly associated with the RNA expression of many other genes, with 293 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP5B1-associated genes across cancer lineages are MIR3660, RN7SL134P, and MIR3913-1. Each is linked with AP5B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5B1-to-partner and partner-to-AP5B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3660 grouped by AP5B1-low versus AP5B1-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5B1→partner) and Y-score (partner→AP5B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	MIR3660 →	+0.364	+7.939	<.001	.008	3	2
CESC	RN7SL134P →	+0.165	+4.874	<.001	.002	3	2
BLCA	MIR3913-1 →	+0.384	+4.082	<.001	.002	3	2
BLCA	NFILZ →	+0.065	+3.996	<.001	.002	3	2
BLCA	RAD54L2P1 →	+0.018	+4.296	<.001	.006	3	2
BRCA	RNU2-47P →	+0.628	+8.055	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 293 associations by consensus.

MIR3660 by AP5B1 expression — PRAD

Explore this box plot interactively →