AP5B1

Across TCGA patient cohorts, AP5B1 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP5B1-associated genes across cancer lineages are CD8+ Tcm, Class-switched memory B-cells, and Fibroblasts. Each is linked with AP5B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5B1-to-partner and partner-to-AP5B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by AP5B1-low versus AP5B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5B1→partner) and Y-score (partner→AP5B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tcm →	+0.018	+2.061	.046	.048	3	1
UCEC	Class-switched memory B-cells →	-0.057	-2.584	.032	.011	3	1
UCEC	Fibroblasts →	+0.025	+1.978	.014	.014	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ Tcm by AP5B1 expression — UCEC

Explore this box plot interactively →