AP5B1

Across TCGA cell cohorts, AP5B1 mutation is significantly associated with the RNA expression of many other genes, with 600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP5B1-associated genes across cancer lineages are RNASE9, OR52E4, and NUPR2. Each is linked with AP5B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP5B1-to-partner and partner-to-AP5B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by AP5B1-low versus AP5B1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP5B1→partner) and Y-score (partner→AP5B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RNASE9 →	+0.005	+5.357	<.001	.001	3	2
BLOOD_Leukemia	OR52E4 →	+0.015	+5.201	<.001	.006	3	1
BLOOD_Leukemia	NUPR2 →	+0.098	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ZCCHC13 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	GRXCR1 →	+0.023	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR11H2 →	+0.074	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

RNASE9 by AP5B1 expression — CNS

Explore this box plot interactively →