AP4E1

Across TCGA pan-cancer cohorts, AP4E1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AP4E1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AP4E1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated AP4E1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LIHC, and HNSC are the cancer types where AP4E1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.965	0.822	.003	36	view →
LIHC	DFS	Median	All	0.116	0.557	<.001	9	view →
HNSC	DFS	Median	II,III,IV	0.354	0.688	.016	7	view →
PRAD	DFS	Median	All	0.072	0.776	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.813	0.558	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AP4E1–UCEC (DFS)

Open the UCEC breakdown →