AP4E1

Across TCGA pan-cancer cohorts, AP4E1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AP4E1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AP4E1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AP4E1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where AP4E1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	III,IV	0.885	0.274	.006	26	view →
LUAD	OS	Median	II,III,IV	0.313	0.924	<.001	15	view →
CCRCC	DFS	Median	All	0.885	0.620	.003	13	view →
LSCC	DFS	Tertile	All	0.545	0.786	.011	10	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
HNSC	DFS	Quartile	All	0.278	1.000	.026	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AP4E1–UCEC (DFS)

Open the UCEC breakdown →