AP4E1

Across TCGA patient cohorts, AP4E1 mutation is significantly associated with the RNA expression of many other genes, with 6,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP4E1-associated genes across cancer lineages are ATF4P2, TARS1, and KIF23. Each is linked with AP4E1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AP4E1-to-partner and partner-to-AP4E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4P2 grouped by AP4E1-low versus AP4E1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4E1→partner) and Y-score (partner→AP4E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	ATF4P2 →	+0.054	+5.174	<.001	.001	3	4
UCEC	TARS1 →	+0.422	+1.362	<.001	.001	3	4
UCEC	KIF23 →	+0.684	+1.673	<.001	<.001	3	4
UCEC	SF3A3 →	+0.345	+1.562	<.001	<.001	3	4
UCEC	POLDIP3 →	+0.560	+2.042	<.001	<.001	3	3
UCEC	HMGXB4 →	+0.418	+1.879	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,183 associations by consensus.

ATF4P2 by AP4E1 expression — LIHC

Explore this box plot interactively →