AP4E1

Across TCGA patient cohorts, AP4E1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP4E1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, FoxM1, and c-Met_pY1235. Each is linked with AP4E1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AP4E1-to-partner and partner-to-AP4E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by AP4E1-low versus AP4E1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4E1→partner) and Y-score (partner→AP4E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p38-MAPK_pT180_Y182 →	-0.390	-3.459	.024	.005	3	3
UCEC	FoxM1 →	+0.243	+2.039	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.048	+1.047	.014	.018	3	3
COAD	Cyclin-B1 →	+0.724	+2.815	.015	.036	3	3
SKCM	IRS1 →	+0.150	+2.321	.048	.035	3	2
UCEC	FASN →	+0.276	+1.192	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

p38-MAPK_pT180_Y182 by AP4E1 expression — SKCM

Explore this box plot interactively →