AP4B1

Across TCGA patient cohorts, AP4B1 mutation is significantly associated with the RNA expression of many other genes, with 3,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP4B1-associated genes across cancer lineages are RN7SL722P, PRELID3BP2, and HAO2-IT1. Each is linked with AP4B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AP4B1-to-partner and partner-to-AP4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL722P grouped by AP4B1-low versus AP4B1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4B1→partner) and Y-score (partner→AP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL722P →	+0.126	+7.471	<.001	.008	3	3
SKCM	PRELID3BP2 →	+0.039	+4.003	<.001	.006	3	3
LUSC	HAO2-IT1 →	+0.395	+4.496	<.001	.007	3	3
LUSC	RN7SL223P →	+0.404	+5.321	<.001	.002	3	3
UCEC	IGLJ7 →	+0.745	+1.509	.001	.002	3	3
COAD	RNU7-53P →	+0.616	+4.399	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,120 associations by consensus.

RN7SL722P by AP4B1 expression — BRCA

Explore this box plot interactively →