AP4B1

Across TCGA patient cohorts, AP4B1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP4B1-associated genes across cancer lineages are eIF4E, p27_pT198, and Caspase-7-cleavedD198. Each is linked with AP4B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP4B1-to-partner and partner-to-AP4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AP4B1-low versus AP4B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4B1→partner) and Y-score (partner→AP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+3.472	.003	.002	3	2
UCEC	p27_pT198 →	+0.105	+2.321	.002	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+1.027	+4.247	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.185	-1.502	.025	.027	3	1
UCEC	ERK2 →	+0.148	+2.000	.019	.009	3	1
UCEC	ACC_pS79 →	+0.284	+2.222	.013	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by AP4B1 expression — UCEC

Explore this box plot interactively →