AP4B1

Across TCGA cell cohorts, AP4B1 mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP4B1-associated genes across cancer lineages are LCE1C, PFN3, and IFNA4. Each is linked with AP4B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP4B1-to-partner and partner-to-AP4B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1C grouped by AP4B1-low versus AP4B1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4B1→partner) and Y-score (partner→AP4B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LCE1C →	+0.062	+5.196	<.001	.005	3	2
CNS	PFN3 →	+0.048	+4.754	<.001	.005	3	1
CNS	IFNA4 →	+0.160	+4.321	<.001	.009	3	1
CNS	FAM240A →	+0.012	+4.169	.004	.008	3	1
LARGE_INTESTINE	SAMM50 →	+0.488	+3.212	.009	.006	3	1
LARGE_INTESTINE	ACRBP →	+0.963	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

LCE1C by AP4B1 expression — OVARY

Explore this box plot interactively →