Across TCGA pan-cancer cohorts, AP4B1-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated AP4B1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AP4B1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AP4B1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, KIRC, and BLCA are the cancer types where AP4B1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.540	0.238	<.001	105	view →
KIRC	DFS	Median	All	0.460	0.706	<.001	76	view →
BLCA	DFS	Median	All	0.430	0.265	.006	59	view →
READ	OS	Tertile	II,III,IV	0.773	0.238	<.001	49	view →
LGG	DFS	Median	All	0.654	0.816	<.001	49	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
KIRP	DFS	Quartile	III,IV	0.105	0.605	.003	32	view →
BRCA	OS	Median	III,IV	0.954	0.846	.003	28	view →
CESC	DFS	Quartile	II,III,IV	0.627	0.851	.014	26	view →
ACC	DFS	Tertile	All	0.528	0.822	.005	26	view →
PRAD	OS	Median	All	0.976	1.000	.010	20	view →
UVM	DFS	Tertile	III,IV	0.304	0.854	.007	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

Exploration

Same gene, other analysis: AP4B1-AS1 tumor-vs-normal RNA expression · all AP4B1-AS1 data types