AP3S2

Across TCGA patient cohorts, AP3S2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP3S2-associated genes across cancer lineages are MEK1, Notch1, and PDCD4. Each is linked with AP3S2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3S2-to-partner and partner-to-AP3S2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by AP3S2-low versus AP3S2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3S2→partner) and Y-score (partner→AP3S2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.540	+3.584	.002	.002	3	1
UCEC	Notch1 →	+0.234	+3.183	<.001	.009	3	1
UCEC	PDCD4 →	-0.583	-2.999	.010	.035	3	1
UCEC	Annexin-1 →	+0.559	+3.019	.028	.019	3	1
UCEC	ATM →	-0.545	-2.459	.012	.020	3	1
UCEC	Caspase-8 →	-0.269	-3.321	.027	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by AP3S2 expression — UCEC

Explore this box plot interactively →