AP3S1

Across TCGA pan-cancer cohorts, AP3S1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AP3S1 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AP3S1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AP3S1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where AP3S1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.022	18	view →
CCRCC	OS	Median	All	0.745	0.924	.010	11	view →
LSCC	DFS	Quartile	All	0.862	1.000	.027	5	view →
UCEC	DFS	Median	All	0.954	0.854	.027	2	view →
GBM	OS	Quartile	All	0.345	0.570	.043	1	view →
LUAD	DFS	Median	All	0.951	0.859	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AP3S1–COAD (DFS)

Open the COAD breakdown →