AP3S1

Across TCGA patient cohorts, AP3S1 mutation is significantly associated with the RNA expression of many other genes, with 563 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP3S1-associated genes across cancer lineages are RN7SKP46, YWHAQP7, and MAP3K4-AS1. Each is linked with AP3S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3S1-to-partner and partner-to-AP3S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP46 grouped by AP3S1-low versus AP3S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3S1→partner) and Y-score (partner→AP3S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP46 →	+0.076	+4.035	<.001	.006	3	2
UCEC	YWHAQP7 →	+0.110	+2.570	.001	<.001	3	1
UCEC	MAP3K4-AS1 →	+0.724	+3.593	.002	.001	3	1
UCEC	CDC37L1-DT →	+0.578	+3.337	.001	.005	3	1
UCEC	TAF9 →	+0.695	+3.480	<.001	.002	3	1
SKCM	RN7SL794P →	+0.234	+3.801	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 563 associations by consensus.

RN7SKP46 by AP3S1 expression — UCEC

Explore this box plot interactively →