AP3S1

Across TCGA patient cohorts, AP3S1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP3S1-associated genes across cancer lineages are ERK2, HSP70, and JNK2. Each is linked with AP3S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3S1-to-partner and partner-to-AP3S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by AP3S1-low versus AP3S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3S1→partner) and Y-score (partner→AP3S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.242	+3.584	.009	.002	3	1
UCEC	HSP70 →	-0.472	-2.459	.014	.020	3	1
UCEC	JNK2 →	+0.261	+2.459	.006	.020	3	1
UCEC	STAT3_pY705 →	-0.402	-2.459	.001	.020	3	1
UCEC	ATM →	-0.590	-2.986	.007	.035	3	1
UCEC	4E-BP1_pT37_T46 →	-0.399	-2.459	.027	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by AP3S1 expression — UCEC

Explore this box plot interactively →