AP3S1

Across TCGA cell cohorts, AP3S1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,311 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AP3S1-associated GO terms across cancer lineages are Interkinetic nuclear migration, Positive regulation of centrosome duplication, and Positive regulation of protein K48-linked ubiquitination. Each is linked with AP3S1 in more than 10 cancer types. Because this analysis shows association rather than direction, both AP3S1-to-partner and partner-to-AP3S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interkinetic nuclear migration grouped by AP3S1-low versus AP3S1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3S1→partner) and Y-score (partner→AP3S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Interkinetic nuclear migration →	+0.140	+1.100	<.001	<.001	3	11
BREAST	Positive regulation of centrosome duplication →	+0.094	+0.928	<.001	<.001	3	10
OVARY	Positive regulation of protein K48-linked ubiquitination →	+0.122	+0.955	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	+0.226	+0.914	.001	.007	3	10
OVARY	Regulation of protein monoubiquitination →	+0.143	+0.851	.005	<.001	3	9
OVARY	Positive regulation of protein monoubiquitination →	+0.143	+0.851	.005	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,311 associations by consensus.

Interkinetic nuclear migration by AP3S1 expression — BREAST

Explore this box plot interactively →