AP3M2

Across TCGA patient cohorts, AP3M2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP3M2-associated genes across cancer lineages are p90 RSK, 14-3-3_beta, and eIF4E. Each is linked with AP3M2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3M2-to-partner and partner-to-AP3M2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by AP3M2-low versus AP3M2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3M2→partner) and Y-score (partner→AP3M2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.147	+1.598	.033	.011	3	2
UCEC	14-3-3_beta →	-0.105	-3.295	.003	.009	3	1
UCEC	eIF4E →	+0.195	+2.321	.010	.001	3	1
UCEC	A-Raf_pS299 →	-0.098	-2.115	.023	.017	3	1
UCEC	Fibronectin →	-0.258	-1.690	.029	.042	3	1
UCEC	JNK2 →	+0.161	+1.763	.024	.048	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p90 RSK by AP3M2 expression — UCEC

Explore this box plot interactively →