Across TCGA patient cohorts, AP3M1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP3M1-associated genes across cancer lineages are p27_pT198, PCNA, and EGFR_pY1068. Each is linked with AP3M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3M1-to-partner and partner-to-AP3M1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3M1→partner) and Y-score (partner→AP3M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.131	+2.321	.005	.034	3	2
UCEC	PCNA →	+0.326	+2.115	<.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.234	-2.115	.033	.019	3	1
UCEC	eIF4E →	+0.188	+3.321	.041	.010	3	1
UCEC	A-Raf_pS299 →	-0.185	-2.321	<.001	.033	3	1
UCEC	FOXO3a_pS318_S321 →	-0.153	-2.459	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

AP3M1 survival (RNA) · tumor vs normal (RNA) · all AP3M1 data types