AP3B2

Across TCGA cell cohorts, AP3B2 mutation is significantly associated with the RNA expression of many other genes, with 138 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP3B2-associated genes across cancer lineages are PRAMEF15, PHF5A, and TLE6. Each is linked with AP3B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3B2-to-partner and partner-to-AP3B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF15 grouped by AP3B2-low versus AP3B2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3B2→partner) and Y-score (partner→AP3B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRAMEF15 →	+0.006	+4.906	<.001	.006	3	1
LARGE_INTESTINE	PHF5A →	+0.536	+3.212	.005	.006	3	1
LARGE_INTESTINE	TLE6 →	+1.011	+3.212	.001	.006	3	1
LARGE_INTESTINE	PIGL →	+0.700	+3.212	.008	.006	3	1
LARGE_INTESTINE	SEPSECS →	+0.819	+3.212	<.001	.006	3	1
LARGE_INTESTINE	TTC19 →	+0.790	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

PRAMEF15 by AP3B2 expression — OESOPHAGUS

Explore this box plot interactively →