AP3B1

Across TCGA cell cohorts, AP3B1 mutation is significantly associated with the RNA expression of many other genes, with 206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP3B1-associated genes across cancer lineages are XAGE5, OR56A3, and GSC. Each is linked with AP3B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP3B1-to-partner and partner-to-AP3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by AP3B1-low versus AP3B1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3B1→partner) and Y-score (partner→AP3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	XAGE5 →	+0.534	+4.643	<.001	.005	3	2
BLOOD_Lymphoma	OR56A3 →	+0.340	+4.523	.007	.004	3	2
BLOOD_Leukemia	GSC →	+1.017	+3.948	<.001	.003	3	1
BLOOD_Leukemia	TMEM196 →	+0.035	+3.289	<.001	.009	3	1
BLOOD_Leukemia	FIGLA →	+0.018	+4.569	<.001	.003	3	1
BLOOD_Leukemia	DEFB108B →	+0.106	+3.684	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 206 associations by consensus.

XAGE5 by AP3B1 expression — BLOOD_Lymphoma

Explore this box plot interactively →