AP3B1

Across TCGA cell cohorts, AP3B1 mutation is significantly associated with the mutation status of many other genes, with 3,532 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AP3B1-associated genes across cancer lineages are PLXNA1, KSR2, and LEPR. Each is linked with AP3B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AP3B1-to-partner and partner-to-AP3B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLXNA1 grouped by AP3B1-low versus AP3B1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP3B1→partner) and Y-score (partner→AP3B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLXNA1 →	+3.510	+4.108	.003	.003	1	5
BONE	KSR2 →	+5.437	+5.437	.003	.003	1	4
BONE	LEPR →	+5.437	+5.437	.003	.003	1	4
BONE	INSRR →	+5.437	+5.437	.003	.003	1	4
OESOPHAGUS	ANKRD17 →	+3.087	+4.000	.008	.008	1	4
BLOOD_Lymphoma	FBXW7 →	+4.247	+4.554	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,532 associations by consensus.

PLXNA1 by AP3B1 expression — BLOOD_Lymphoma

Explore this box plot interactively →