AP2M1

Across TCGA patient cohorts, AP2M1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP2M1-associated genes across cancer lineages are ATM, Gab2, and JNK2. Each is linked with AP2M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2M1-to-partner and partner-to-AP2M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by AP2M1-low versus AP2M1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2M1→partner) and Y-score (partner→AP2M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.379	-1.847	.022	.008	3	2
UCEC	Gab2 →	+0.292	+2.321	.026	.034	3	1
UCEC	JNK2 →	+0.209	+1.502	.004	.030	3	1
UCEC	MEK1 →	+0.332	+2.247	.013	.001	3	1
UCEC	MSH2 →	-0.204	-1.848	.016	.049	3	1
UCEC	p27_pT157 →	-0.050	-1.502	.017	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by AP2M1 expression — UCEC

Explore this box plot interactively →