AP2M1

Across TCGA cell cohorts, AP2M1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AP2M1-associated genes across cancer lineages are LMX1A, GP9, and MTRNR2L10. Each is linked with AP2M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2M1-to-partner and partner-to-AP2M1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMX1A grouped by AP2M1-low versus AP2M1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2M1→partner) and Y-score (partner→AP2M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LMX1A →	+0.098	+3.239	<.001	.004	3	2
CNS	GP9 →	+0.019	+4.169	<.001	.008	3	1
CNS	MTRNR2L10 →	+0.010	+4.772	<.001	.002	3	1
BLOOD_Leukemia	GTSF1L →	+0.527	+3.619	.001	.007	3	1
BLOOD_Leukemia	UCMA →	+0.052	+2.926	.001	.009	3	1
BLOOD_Leukemia	DEFB108B →	+0.084	+3.269	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

LMX1A by AP2M1 expression — BLOOD_Leukemia

Explore this box plot interactively →