AP2B1P1

Across TCGA patient cohorts, AP2B1P1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,082 significant associations in total. OV shows the largest number of these associations.

The most reproducible AP2B1P1-associated GO terms across cancer lineages are Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Rescue of stalled ribosome, and COPII-coated vesicle cargo loading. Each is linked with AP2B1P1 in more than 28 cancer types. Because this analysis shows association rather than direction, both AP2B1P1-to-partner and partner-to-AP2B1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by AP2B1P1-low versus AP2B1P1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2B1P1→partner) and Y-score (partner→AP2B1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.064	+0.203	<.001	<.001	3	29
DLBC	Rescue of stalled ribosome →	+0.061	+0.157	<.001	<.001	3	28
DLBC	COPII-coated vesicle cargo loading →	+0.099	+0.157	<.001	<.001	3	28
ESCA	Histone mRNA metabolic process →	+0.061	+0.208	.003	<.001	3	28
DLBC	Positive regulation of mRNA processing →	+0.077	+0.166	<.001	<.001	3	27
ESCA	Protein depolymerization →	+0.050	+0.259	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,082 associations by consensus.

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by AP2B1P1 expression — LAML

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