AP2B1

Across TCGA cell cohorts, AP2B1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible AP2B1-associated genes across cancer lineages are IL3, PRAMEF10, and PRAMEF17. Each is linked with AP2B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2B1-to-partner and partner-to-AP2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by AP2B1-low versus AP2B1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2B1→partner) and Y-score (partner→AP2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	C18orf63 →	+0.019	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IL3 by AP2B1 expression — LUNG_SCLC

Explore this box plot interactively →