AP2A2

Across TCGA patient cohorts, AP2A2 mutation is significantly associated with the RNA expression of many other genes, with 1,870 significant associations in total. COAD shows the largest number of these associations.

The most reproducible AP2A2-associated genes across cancer lineages are CDCA8, MCM10, and PRC1. Each is linked with AP2A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AP2A2-to-partner and partner-to-AP2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA8 grouped by AP2A2-low versus AP2A2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A2→partner) and Y-score (partner→AP2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDCA8 →	+0.762	+2.119	<.001	.003	3	4
COAD	MCM10 →	+0.575	+3.740	.002	<.001	3	4
SKCM	PRC1 →	+0.636	+3.510	.001	.002	3	3
COAD	ANKRD39 →	+0.351	+3.352	.002	.005	3	3
COAD	CENPS-CORT →	+0.368	+3.740	<.001	<.001	3	3
UCEC	SKA1 →	+0.554	+1.595	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,870 associations by consensus.

CDCA8 by AP2A2 expression — SKCM

Explore this box plot interactively →