AP2A2

Across TCGA patient cohorts, AP2A2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP2A2-associated genes across cancer lineages are MEK1, PCNA, and ATM. Each is linked with AP2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2A2-to-partner and partner-to-AP2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by AP2A2-low versus AP2A2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A2→partner) and Y-score (partner→AP2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MEK1 →	+0.306	+3.017	.001	.017	3	2
COAD	PCNA →	+0.317	+3.330	.006	.005	3	2
UCEC	ATM →	-0.705	-3.321	<.001	<.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.642	+3.330	<.001	.005	3	2
SKCM	Cyclin-B1 →	+0.514	+3.334	.006	.005	3	2
UCEC	EGFR_pY1068 →	-0.190	-1.765	.043	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MEK1 by AP2A2 expression — COAD

Explore this box plot interactively →