AP2A2

Across TCGA cell cohorts, AP2A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,207 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AP2A2-associated GO terms across cancer lineages are Cellular detoxification of methylglyoxal, Telomere tethering at nuclear periphery, and Response to methylglyoxal. Each is linked with AP2A2 in more than 13 cancer types. Because this analysis shows association rather than direction, both AP2A2-to-partner and partner-to-AP2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular detoxification of methylglyoxal grouped by AP2A2-low versus AP2A2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A2→partner) and Y-score (partner→AP2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Cellular detoxification of methylglyoxal →	+0.145	+1.148	.001	<.001	3	14
BREAST	Telomere tethering at nuclear periphery →	+0.137	+1.137	<.001	<.001	3	14
URINARY_TRACT	Response to methylglyoxal →	+0.145	+1.148	.001	<.001	3	14
URINARY_TRACT	Cellular response to methylglyoxal →	+0.145	+1.148	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.088	+1.214	<.001	<.001	3	13
BREAST	Telomere localization →	+0.159	+0.841	<.001	.009	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,207 associations by consensus.

Cellular detoxification of methylglyoxal by AP2A2 expression — URINARY_TRACT

Explore this box plot interactively →