Across TCGA patient cohorts, AP2A1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP2A1-associated genes across cancer lineages are Ku80, MSH2, and NF2. Each is linked with AP2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP2A1-to-partner and partner-to-AP2A1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP2A1→partner) and Y-score (partner→AP2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.184	+1.672	.013	.006	3	2
UCEC	MSH2 →	-0.329	-3.143	<.001	<.001	3	2
UCEC	NF2 →	+0.162	+1.137	.017	.041	3	2
UCEC	ATM →	-0.565	-3.156	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.080	-1.780	.011	.024	3	1
UCEC	eEF2 →	+0.294	+1.353	.008	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

AP2A1 survival (RNA) · tumor vs normal (RNA) · all AP2A1 data types